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第一部分 奋斗历程1

刘耕陶院士简历3

人生七十忆往事5

第二部分 学术贡献11

一、刘耕陶院士的学术贡献和学术思想13

二、刘耕陶院士的主要学术论文17

A Novel Antihepatitis Drug，Bicyclol，Prevents Liver Carcinogenesis in Diet hylnitrosamine-Initiated and Phenobarbital-Promoted Mice Tumor Model17

H1，A Derivative of Tetrandrine，Exerts Anti-MDR Activity by Initiating Intrinsic Apoptosis Pathway and Inhibiting the Activation of Erk1/2 and Akt1/227

5-Bromotetrandrine Enhances the Sensitivity of Doxorubicin-induced Apoptosis in Intrinsic Resistant Human Hepatic Cancer Be17402 Cells40

The Novel Squamosamide Derivative FLZ Enhances BDNF/TrkB/CREB Signaling and Inhibits Neuronal Apoptosis in APP/PS1 Mice49

Bicyclol Protects Hep G2 Cells Against D-galactosamine-Induced Apoptosis Through Inducing Heat Shock Protein 27 and Mitochondria Associated Pathway60

Compound FLZ Inhibits Lipopolysaccharid e-induced Inflammatory Effects Via Down-regulation of the TAK-IKK and TAK-JNK/p38MAPK Pathways in RAW264.7 Macrophages69

Bicyclol：A Novel Drug for Treating Chronic Viral Hepatitis B and C80

Protective Effects of Compound FLZ， A Novel Synthetic Analogue of Squamosamide，on β3-amyloid-induced Rat Brain Mitochondrial Dysfunction in vitro97

Establishment of a HPLC Method for Preclinical Pharmacokinetic Study of the Novel anti-Parkinson’s Disease Candidate Drug FLZ in Rats106

Bicyclol：A Novel Antihepatitis Drug with Hepatic Heat Shock Protein 27/70-inducing Activity and Cytoprotective Effects in Mice112

The Novel Squamosamide Derivative（Compound FLZ） Attenuated 1-methyl，4-phenyl-pyridinium Ion（MPP＋）-induced Apoptosis and Alternations of Related Signal Transduction in SH-SY5Y Cells122

The Protective Action of Scutellarin Against Immunological Liver Injury Induced by Concanavalin A and its Effect on Pro-inflammatory Cytokines in Mice131

A Novel Cyclic Squamosamide Analogue Compound FLZ Improves Memory Impairment in Artificial Senescence Mice Induced by Chronic Injection of D-Galactose and NaNO2139

Chemopreventive Effect of Bicyclol on Malignant Transformation of WB-F344 Rat Liver Epithelial Cells and Its Effect on Related Signal Transduction in vitro148

Effects of Bicyclol on Dimethylnitrosamine-induced Liver Fibrosis in Mice and Its Mechanism of Action158

Protective Effects of Compound FLZ on β3-amyloid Peptide-（25-35）-induced Mouse Hippocampal Injury and Learning and Memory Impairment167

Chemopreventive Effect of Dimethyl Dicarboxylate Biphenyl on Malignant Transformation of WB-F344 Rat Liver Epithelial Cells175

Toxicity of Novel Anti-hepatitis Drug Bicyclol：A Preclinical Study181

Mechanism of Protective Action of Bicyclol Against CCl4-induced Liver Injury in Mice191

Effect of Diphenyl Dimethyl Bicarboxylate on Concanavalin A-induced Liver Injury in Mice200

Pharmacological Study of the Novel Compound FLZ Against Experimental Parkinson’s Models and Its Active Mechanism210

Inhibition of Fas/FasL mRNA Expression and TNF-α Release in Concanavalin A-induced Liver Injury in Mice by Bicyclol215

Effect of PYCNOGENOL？ on the Toxicity of Heart，Bone Marrow and Immune Organs as Induced by Antitumor Drugs222

Antioxidative Activity of Natural Isorhapontigenin227

Effects of Salvianolic Acid A on Oxygen Radicals Released by Rat Neutrophils and on Neutrophil Function233

Role of Nintic Oxide in Immunological Liver Damage in Mice238

双环醇对实验性肝纤维化的防护作用及分子机制244

病毒性肝炎发病的免疫学机制与抗肝炎新药研究的思考253

P-糖蛋白引起的肿瘤多药耐药及其逆转261

国家一类抗肝炎新药双环醇片266

对我国慢性病毒性肝炎防治与研究工作的建议269

双环醇的抗病毒与肝细胞保护作用及其作用机制273

治疗慢性病毒性肝炎药物的现状与未来278

人参叶总皂甙对老龄大鼠白细胞介导的防御功能的影响281

治疗慢性病毒性肝炎药物的现状及未来发展的思考286

一氧化氮在小鼠肝损伤中的作用288

药物代谢酶与免疫系统——机体的“清洁”系统294

黄褐毛忍冬皂甙对对乙酰氨基酚致小鼠肝脏毒性的保护作用297

联苯双酯对致癌物损伤大鼠肝细胞的保护作用301

五味子乙素和五味子酚对药物代谢Ⅱ相酶及雌二醇代谢的影响305

蕊木宁抗四氯化碳肝损伤的作用原理310

从五味子的研究到联苯双酯的发现315

联苯双酯对小鼠肝损伤保护作用的进一步研究323

五味子乙素对小鼠肝细胞微粒体细胞色素P-450的诱导作用329

紫芝和赤芝酒提物对小鼠肝脏的一些药理作用336

联苯双酯、二苯乙烯、五仁醇及灵芝对小鼠实验性肝损伤保护作用的比较341

三、刘耕陶院士的主要学术著作349

当代药理学（第二版）349

中药药理研究与药物创新395

中草药现代研究（第五卷）401

当代药理学（第一版）407

人参的研究及栽培413

四、刘耕陶院士学术年表416

刘耕陶院士主要论文目录416

刘耕陶院士主要著作目录429

刘耕陶院士主要荣誉目录430

第三部分 治学之道431

求索治肝路433

创新与埋头实干437

中医药现代化的关键是找准突破口444

中药研究大有可为446

如何从中草药研发新药449

难忘的2008年453

第四部分 社会影响457

刘耕陶：“肝”胆过人觅“良方”459

刘耕陶：“肝”胆过人觅“药方”462

扶正培本 耕耘不止——记刘耕陶院士的科研项目及成果467

中药新药研发是一个复杂的系统工程469

中药攻克世界性难题可有所为——访中国工程院院士刘耕陶471

桑榆未晚霞满天——记我国著名药理学家、中国工程院院士刘耕陶院士475

从中药五味子研究中开发出联苯双酯和双环醇抗肝炎创新药物的开拓者——记2007年度中国药学发展奖天士力创新药物奖特别贡献奖获得者刘耕陶院士477

牛背上走来的工程院院士——我国著名的生化药理学家、中国工程院院士刘耕陶的传奇人生479

刘耕陶：乙肝歧视已影响国家发展483

新药研发 箭在弦上——访中国医学科学院药物研究所刘耕陶教授486

刘耕陶：找准突破口489

就这样忘我地工作491

把丢了的金子捡回来——访著名生化药理学家刘耕陶院士493

第五部分 真情感念497

我国肝脏药理学研究的奠基人——刘耕陶院士499

沉痛缅怀著名药理学家我刊名誉顾问刘耕陶院士500

缅怀挚友刘耕陶院士502

忆刘耕陶老师503

刘先生，我们想念您504

深切怀念刘耕陶同学505

怀念506

永远的榜样508

永远的怀念 前行的动力509

热恋科学的精神永存510

师恩浩瀚，情深如父511

深切怀念我的恩师刘耕陶教授514

念恩师刘耕陶515

深切怀念刘耕陶院士516

鲜花一束，飞入九重云霄518

怀念恩师520

纪念我的恩师刘耕陶院士522

怀念恩师刘耕陶院士523

纪念刘老师524

第六部分 人生风采527

精彩人生529

科研工作532

学术活动534

国际交流538

珍贵合影541