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Development of the Cardiovascular System1

Cardiogenesis in the Drosophila Model: Control Mechanisms during Early Induction and Diversification of Cardiac Progenitors S. Zaffran, X. Xu, P.C.H. Lo, H.-H. Lee, and M. Frasch1

Regulation of Cardiac Muscle Differentiation in Xenopus laevis Embryos T. Mohun, B. Latinkic, N. Towers, and S. Kotecha13

Genetic Regulation of Cardiac Patterning in Zebrafish D. Yelon, J.L. Feldman, and B.R. Keegan19

Zebrafish Hearts and Minds: Nodal Signaling in Cardiac and Neural Left-Right Asymmetry S. Long, N. Ahmad, and M. Rebagliati27

Cardiac Left-Right Development: Are the Early Steps Conserved? K.L. Kramer and H.J Yost37

Erythropoietin and Retinoic Acid Signaling in the Epicardium Is Required for Cardiac Myocyte Proliferation I. Stuckmann and A.B. Lassar45

Endocardial Cushion Formation in Zebrafish D.Y.R. Stainier, D. Beis, B. Jungblut, and T. Bartman49

Neural Crest Migration and Mouse Models of Congenital Heart Disease A.D. Gitler, C.B. Brown, L. Kochilas, J. Li, and J.A. Epstein57

Transcription Factors in Cardiovascular Development63

Hey bHLH Factors in Cardiovascular Development A. Fischer, C. Leimeister, C. Winkler,N. Schumacher, B. Klamt, H. Elmasri, C. Steidl, M. Maier, K.-P. Knobeloch, K. Amann,A. Helisch, M. Sendtner, and M. Gessler63

Molecular Mechanisms of Chamber-specific Myocardial Gene Expression: Transgenic Analysis of the ANF Promoter E.M. Small andP.A. Krieg71

Pitx Genes during Cardiovascular Development C. Kioussi, P. Briata, S.H. Baek,A. Wynshaw-Boris, D.W. Rose, and M.G. Rosenfeld81

Pitx2 and Cardiac Development: A Molecular Link between Left/Right Signaling and Congenital Heart Disease M. Campione, L. Acosta, S. Martinez, J.M. Icardo, A. Aranega,and D. Franco89

Regulation of Cardiac Growth and Development by SRF and Its Cofactors D. Wang, R. Passier,Z.-P. Liu, C.H. Shin, Z. Wang, S. Li, L.B. Sutherland, E. Small, P.A. Krieg, and E.N. Olson97

Homeodomain Factor Nkx2-5 in Heart Development and Disease R.P. Harvey, D. Lai, D. Elliott,C. Biben, M. Solloway, O. Prall, F. Stennard, A. Schindeler, N. Groves, L. Lavulo, C. Hyun,T. Yeoh, M. Costa, M. Furtado, and E. Kirk107

Causes of Clinical Diversity in Human TBX5 Mutations T. Huang, J.E. Lock, A.C. Marshall,C. Basson, J.G. Seidman, and C.E. Seidman115

Molecular Mechanisms of Ventricular Hypoplasia D. Srivastava, P.D. Gottlieb, and E.N. Olson121

Hypoxia, HIFs, and Cardiovascular Development M.C. Simon, D. Ramirez-Bergeron, F. Mack,C.-J Hu, Y. Pan, and K. Mansfield127

Quiescent Hypervascularity Mediated by Gain of HIF-ltx Function J.M. Arbeit133

Vascular Biology143

The Diverse Roles of Integrins and Their Ligands in Angiogenesis R.O.Hynes, J.C. Lively,J.H. McCarty, D. Taverna, S.E. Francis, K. Hodivala-Dilke, and Q. Xiao143

Arteries, Veins, Notch, and VEGF B.M. Weinstein and N.D. Lawson155

Cell Cycle Signaling and Cardiovascular Disease E.G. Nabel, M. Boehm, L.M. Akyurek, T. Yoshimoto, M.F. Crook, M. Olive, H. San, and X. Qu163

Selective Functions of Angiopoietins and Vascular Endothelial Growth Factor on Blood Vessels: The Concept of"Vascular Domain" T.N. Sato, S. Loughna, E.C. Davis, R.P. Visconti, and C.D. Richardson171

Survival Mechanisms of VEGF and PIGF during Microvascular Remodeling J.N. Upalakalin,I. Hemo, C. Dehio, E. Keshet, and L.E. Benjamin181

Molecular Mechanisms of Lymphangiogenesis T. Makinen and K. Alitalo189

Protease-activated Receptors in the Cardiovascular System S.R. Coughlin197

Migration of Monocytes/Macrophages In Vitro and In Viva Is Accompanied by MMP 12-dependent Tunnel Formation and by Neovascularization M. Anghelina, A. Schmeisser, P. Krishnan, L. Moldovan, R.H. Strasser, and N.I. Moldovan209

The Role of EG-VEGF in the Regulation of Angiogenesis in Endocrine Glands J. LeCouter, R. Lin, and N. Ferrara217

Profiling the Molecular Diversity of Blood Vessels R. Pasqualini and W. Arap223

Tumor Angiogenesis227

VEGF-A Induces Angiogenesis, Arteriogenesis, Lymphangiogenesis, and Vascular Malformations J.A. Nagy, E. Vasile, D. Feng, C. Sundberg, L.F. Brown, E.J. Manseau, A.M. Dvorak, and H.F. Dvorak227

Angiogenesis and Lymphangiogenesis in Tumors: Insights from Intravital Microscopy R.K. Jain239

A Genetic Approach to Understanding Tumor Angiogenesis R. Benezra, P. de Candia, H. Li, E. Romero, D Lyden, S. Rafii, and M. Ruzinova249

Discovery of Type IV Collagen Non-collagenous Domains as Novel Integfin Ligands and Endogenous Inhibitors of Angiogenesis R. Kalluri255

Complementary and Coordinated Roles of the VEGFs and Angiopoietins during Normal and Pathologic Vascular Formation N. W. Gale, G. Thurston, S. Davis, S.J. Wiegand, J. Holash, J.S. Rudge, and G.D. Yancopoulos267

Involvement of G Proteins in Vascular Permeability Factor/Vascular Endothelial Growth Factor Signaling D. Mukhopadhyay and H. Zeng275

Targeted Delivery of Mutant Raf Kinase to Neovessels Causes Tumor Regression J.D. Hood and D.A. Cheresh285

Combining Antiangiogenic Agents with Metronomic Chemotherapy Enhances Efficacy against Late-stage Pancreatic Islet Carcinomas in Mice G. Bergers and D. Hanahan293

Genetics and Genomics of the Cardiovascular System301

Zebrafish: The Complete Cardiovascular Compendium C.A. MacRae and M.C. Fishman301

Consomic Rats for the Identification of Genes and Pathways Underlying Cardiovascular Disease R.J. Roman, A. W. Cowley, Jr., A. Greene, A.E. Kwitek, P.J. Tonellato, and H.J. Jacob309

A Mouse Model of Congenital Heart Disease: Cardiac Arrhythrnias and Atrial Septal Defect Caused by Haploinsufticiency of the Cardiac Transcription Factor Csx/Nkx2.5 M. Tanaka,C.I. Berul, M. Ishii, P.Y. Jay, H. Wakaimoto, P. Douglas, N. Yamasaki, T. Kawamoto,J. Gehrmann, C.T. Maguire, M. Schinke, C.E. Seidman, J.G. Seidman, Y. Kurachi, and S. Izumo317

Genetic Dissection of the DiGeorge Syndrome Phenotype F. Vitelli, E.A. Lindsay, and A. Baldini327

A Missense Mutation in a Highly Conserved Region of CASQ2 Is Associated with AutosomalRecessive Catecholamine-induced Polymorphic Ventricular Tachycardia in Bedouin Families from Israel M. Eldar, E. Pros, and H. Lahat333

Regulation of the Heart339

Calcium-dependent Gene Regulation in Myocyte Hypertrophy and Remodeling R.S. Williams and P. Rosenberg339

A Gradient of Myosin Regulatory Light-chain Phosphorylation across the Ventricular Wall Supports Cardiac Torsion J.S. Davis, S. Hassanzadeh, S. Winitsky, H. Wen, A. Aletras, and N.D. Epstein345

Molecular and Functional Maturation of the Murine Cardiac Conduction System S. Rentschler, G.E. Morley, and G.I. Fishman353

The Yin/Yang of Innate Stress Responses in the Heart D.L. Mann363

Regulatory Networks Controlling Mitochondrial Energy Production in the Developing, Hypertrophied, and Diabetic Heart B.N. Finck, J.J. Lehman, P.M. Barger, and D.P. Kelly371

Heart Disease and Failure383

Molecular Epidemiology of Hypertrophic Cardiomyopathy H. Morita, S.R. DePalma, M. Arad, B. McDonough, S. Barr, C. Duffy, B.J. Maron, C.E. Seidman, and J.G. Seidman383

The Sarcoglycan Complex in Striated and Vascular Smooth Muscle M.T. Wheeler, M.J. AlliKian, A. Heydemann, and E.M. McNally389

The MLP Family of Cytoskeletal Z Disc Proteins and Dilated Cardiomyopathy: A Stress Pathway Model for Heart Failure Progression M. Hoshijima, M. Pashmforoush, R. Knoll, and K.R. Chien399

From Sarcomeric Mutations to Heart Disease: Understanding Familial Hypertrophic Cardiomyopathy A. Maass, J.P. Konhilas, B.L. Stauffer, and L.A. Leinwand409

Vascular Endothelium in Tissue Remodeling: Implications for Heart Failure S.M. Dallabrida and M.A. Rupnick417

Using a Gene-switch Transgenic Approach to Dissect Distinct Roles of MAP Kinases in Heart Failure B.G. Petrich, P. Liao, and Y. Wang429

G-Protein-coupled Receptor Function in Heart Failure S.V. Naga Prasad, J. Nienaber, and H.A. Rockman439

Hypertension, Atherosclerosis, and Lipid Homeostasis445

Salt and Blood Pressure: New Insight from Human Genetic Studies R.P. Lifton, F.H. Wilson, K.A. Choate, and D.S. Geller445

Gene-targeting Studies of the Renin-Angiotensin System: Mechanisms of Hypertension and Cardiovascular Disease S.B. Gurley, T.H. Le, and T.M. Coffman451

Modulation of Endothelial NO Production by High-density Lipoprotein C. Mineo and P.W. Shaul459

Plaque Angiogenesis: Its Functions and Regulation K.S. Moulton471

Extracellular Superoxide Dismutase, Uric Acid, and Atherosclerosis H.U. Hink and T. Fukai483

SREBPs: Transcriptional Mediators of Lipid Homeostasis J.D. Horton, J.L. Goldstein, and M.S. Brown491

Genetic Defenses against Hypercholesterolemia H.H. Hobbs, G.A. Graf, L. Yu, K.R. Wilund, and J.C Cohen499

Repairing the Cardiovascular System507

Insulin-like Growth Factor Isoforms in Skeletal Muscle Aging, Regeneration, and Disease N. Winn, A. Paul, A. Musaro, and N. Rosenthal507

Cellular Therapies for Myocardial Infarct Repair C.E. Murry, M.L. Whitney, M.A. Laflamme, H. Reinecke, and L.J. Field519

Gene Therapy for Cardiac Arrhythmias E. Marban, H.B. Nuss, and J.K. Donahue527

Myocardial Disease in Failing Hearts: Defective Excitation-Contraction Coupling X.H.T. Wehrens and A.R. Marks533

Summary: The Coming of Age of Cardiovascular Science C.E. Seidman and J.G. Seidman543

Author Index551

Subject Index553