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High-Yield细胞与分子生物学 第3版PDF|Epub|txt|kindle电子书版本网盘下载
- 罗纳德·W·杜德克主编 著
- 出版社： 北京：北京大学医学出版社
- ISBN：9787565904790
- 出版时间：2013
- 标注页数：151页
- 文件大小：41MB
- 文件页数：166页
- 主题词：人体细胞学－细胞生物学－医师－资格考试－美国－自学参考资料－英文；分子生物学－医师－资格考试－美国－自学参考资料－英文
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图书目录
1 Chromosomal DNA1
Ⅰ．The Biochemistry of Nucleic Acids1
Ⅱ．Levels of DNA Packaging2
Ⅲ．Centromere4
Ⅳ．Heterochromatin4
Ⅴ．Euchromatin4
Ⅵ．Studying Human Chromosomes4
Ⅶ．Staining of Chromosomes5
Ⅷ．Chromosome Morphology6
Ⅸ．DNA Melting Curve7
2 Chromosome Replication9
Ⅰ．General Features9
Ⅱ．The Chromosome Replication Process9
Ⅲ．DNA Topoisomerases11
Ⅳ．The Telomere12
Ⅴ．DNA Damage12
Ⅵ．DNA Repair13
Ⅶ．Clinical Considerations14
Ⅷ．Summary of Chromosome Replication Machinery16
3 Meiosis and Genetic Recombination17
Ⅰ．Meiosis17
Ⅱ．Genetic Recombination19
4 The Human Nuclear Genome22
Ⅰ．General Features22
Ⅱ．Protein-Coding Genes23
Ⅲ．RNA-Coding Genes24
Ⅳ．Epigenetic Control25
Ⅴ．Noncoding DNA25
5 The Human Mitochondrial Genome29
Ⅰ．General Features29
Ⅱ．The 13 Protein-Coding Genes29
Ⅲ．The 24 RNA-Coding Genes29
Ⅳ．Other Mitochondrial Proteins31
Ⅴ．Mitochondrial Diseases31
6 Protein Synthesis33
Ⅰ．General Features33
Ⅱ．Transcription33
Ⅲ．Processing the RNA Transcript into mRNA34
Ⅳ．Translation35
Ⅴ．Clinical Considerations37
7 Control of Gene Expression39
Ⅰ．General Features39
Ⅱ．Mechanism of Gene Expression39
Ⅲ．The Structure of DNA-Binding Proteins41
Ⅳ．Other Mechanisms of Gene Expression44
Ⅴ．The Lac Operon46
Ⅵ．The trp Operon47
8 Mntations of the DNA Sequence49
Ⅰ．General Features49
Ⅱ．Silent(Synonymous)Mutations49
Ⅲ．Non-Silent(Nonsynonymous)Mutations50
Ⅳ．Loss of Function and Gain of Function Mutations55
Ⅴ．Other Types of Polymorphisms56
9 Proto-Oncogenes,Oncogenes,and Tumor-Suppressor Genes58
Ⅰ．Proto-Oncogenes and Oncogenes58
Ⅱ．Tumor-Suppressor Genes60
Ⅲ．Hereditary Cancer Syndromes62
10 The Cell Cycle66
Ⅰ．Mitosis66
Ⅱ．Control of the Cell Cycle68
11 Molecular Biology of Cancer71
Ⅰ．The Development of Cancer(Oncogenesis)71
Ⅱ．The Progression of Cancer72
Ⅲ．Signal Transduction Pathways73
12 Cell Biology of the Immune System77
Ⅰ．Neutrophils(Polys,Segs,or PMNs)77
Ⅱ．Eosinophils78
Ⅲ．Basophils78
Ⅳ．Mast Cells78
Ⅴ．Monocytes79
Ⅵ．Macrophages(Histiocytes;Antigen-Presenting Cells)80
Ⅶ．Natural Killer CDl6+Cell81
Ⅷ．B Lymphocyte81
Ⅸ．T Lymphocyte83
Ⅹ．Immune Response to Exogenous Protein Antigens85
Ⅺ．Immune Response to Endogenous Antigens(Intracellular Virus or Bacteria)86
Ⅻ．Cytokines87
13 Molecular Biology of the Immune System89
Ⅰ．Clonal Selection Theory89
Ⅱ．The B Lymphocyte(B Cell)89
Ⅲ．The T Lymphocyte(T Cell)93
Ⅳ．Clinical Considerations95
Ⅴ．Disorders of Phagocytic Function96
Ⅵ．Systemic Autoimmune Disorders97
Ⅶ．Organ-Specific Autoimmune Disorders97
14 Molecular Biology Techniques100
Ⅰ．Action of Restriction Enzymes101
Ⅱ．Electrophoresis103
Ⅲ．The Enzymatic Method of DNA Sequencing105
Ⅳ．Southern Blotting and Prenatal Testing for Sickle Cell Anemia107
Ⅴ．Isolating a Human Gene by DNA Cloning109
Ⅵ．Construction of cDNA Library111
Ⅶ．Polymerase Chain Reaction113
Ⅷ．Producing a Protein from a Cloned Gene115
Ⅸ．Site-Directed Mutagenesis and Knockout Animals117
Ⅹ．Northern Blot(mRNA)119
Ⅺ．Western Blot(Protein)121
Ⅻ．Human Immunodeficiency Virus(HIV)Structure123
ⅩⅢ．Ligase Chain Reaction(LCR)125
ⅩⅣ．Flow Cytometry127
15 Identification of Human Disease Genes129
Ⅰ．General Features129
Ⅱ．Identification of a Human Disease Gene Through a Chromosome Abnormality129
Ⅲ．Identification of a Human Disease Gene Through Pure Transcript Mapping130
Ⅳ．Identification of a Human Disease Gene Through Large Scale DNA Sequencing131
Ⅴ．Identification of a Human Disease Gene Through Comparison of Human and Mouse Maps132
16 Gene Therapy133
Ⅰ．Gene Therapy133
Ⅱ．Ex Vivo and In Vivo Gene Therapy134
Ⅲ．Integration into Host Cell Chromosomes or as Episomes134
Ⅳ．Viral Vectors Used in Gene Therapy134
Ⅴ．Nonviral Vectors Used in Gene Therapy135
Appendix 1:The Genetic Code137
Appendix 2:Amino Acids138
Appendix 3:Chromosomal Locations of Human Genetic Diseases139
Figure Credits145
Index147