威廉姆斯血液病学 英文原版PDF|Epub|txt|kindle电子书版本网盘下载

威廉姆斯血液病学 英文原版PDF格式电子书版下载

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PART I CLINICAL EVALUATION OF THE PATIENT3

CHAPTER 1 APPROACH TO THE PATIENT [Ernest Beutler/Marshall A. Lichtman/Barry S. Coller/Thomas J. Kipps/Uri Seligsohn/William J. Williams]3

CHAPTER 2 EXAMINATION OF THE BLOOD [Daniel H. Ryan]9

CHAPTER 3 EXAMINATION OF THE MARROW [Daniel H.Ryan]17

CONTRIBUTORS19

PREFACE25

SI UNIT CONVERSION TABLE27

PART II GENERAL HEMATOLOGY29

CHAPTER 4 STRUCTURE OF THE MARROW AND THE HEMATOPOLETIC MICROENVIRONMENT [Camille N. Abboud/Marshall A. Lichtman]29

CHAPTER 5 THE LYMAPOID TISSUES [Thomas J. Kipps]59

CHAPTER 6 THE INFLAMMATORY RESPONSE [Jeffrey S. Warren/Peter A. Ward]67

CHAPTER 7 HEMATOLOGY OF THE NEWBORN [George B. Segel/James Palis]77

CHAPTER 8 HEMATOLOGY IN THE AGED [Marshall A. Lichtman/William J. Williams]93

PART III MOLECULAR AND CELLULAR HEMATOLOGY103

CHAPTER 9 GENETIC PRINCIPLES AND MOLECULAR BIOLOGY [Ernest Beutler]103

CHAPTER 10 CYTOGENETICS AND GENE REARRANGEMENT [Michelle M. LeBeau]115

CHAPTER 11 APOPTOSIS [Roberta A. Gottlieb]125

CHAPTER 12 CELL CYCLE REGULATION AND HEMATOLOGICAL DISORDERS [Mathias Schmid/Dennis A. Carson]131

CHAPTER 13 THE CLUSTER OF DIFFERENTIATION ANTIGENS [Thomas J. Kipps]141

CHAPTER 14 HEMATOPOIETIC STEM CELLS. PROGENITOR CELLS. AND CYTOKINES [Peter J. Quesenberry/Gerald A. Colvin]153

CHAPTER 15 IMMUNE ACCESSORY MOLECULES AND SIGNAL TRANSDUCTION [Theodore J. Yun/Edward A. Clark]175

PART IV THERAPEUTIC PRINCIPLES185

CHAPTER 16 PHARMACOLOGY AND TOXICITY OF ANTINEOPLASTIC DRUGS [Bruce A. Chabner/Wyndham Wilson/Jeffrey Supko]185

CHAPTER 17 TREATMENT OF INFECTIONS IN THE IMMUNOCOMPROMISED HOST [Sreven M. Beutler]201

CHAPTER 18 ALLOGENEIC AND AUTOLOGOUS HEMATOPOIETIC CELL TRANSPLANTATION [Robert S. Negrin/Karl G. Blume]209

CHAPTER 19 GENE THERAPY[Christopher E. Walsh/Johnson M. Liu/Arthur W. Nienhuis]249

CHAPTER 20 THE USE OF VENOUS ACCESS DEVICES [McDonald K. Horne,Ⅲ/Donna Jo Mayo/Alison G. Freifeld]257

CHAPTER 21 PAIN MANAGEMENT [Richard B. Patt/Neil M. Ellison]261

CHAPTER 22 MORPHOLOGY OF THE ERYTHRON [Brian S. Bull]271

PART V THE ERYTHROCYTE271

CHAPTER 23 COMPOSITION OF THE ERYTHROCYTE [Ernest Beutler]289

CHAPTER 24 IRON METABOLISM [Virgil F. Fairbanks/Ernest Beutler]295

CHAPTER 25 METABOLIC ASPECTS OF FOLIC ACID AND COBALAMIN [Bernard M. Babior]305

CHAPTER 26 ENERGY METABOLISM AND MAINTENANCE OF ERYTHROCYTES [Ernest Beutler]319

CHAPTER 27 THE RED CELL MEMBRNAE [Patrick G Gallagher/Bernard G. Forget]333

CHAPTER 28 STRUCTURE AND FUNCTION OF HEMOGLOBIN [Helen M. Ranney/Vijay Sharma]345

CHAPTER 29 PRODUCTION AND DESTRUCTION OF ERYTHROCYTES [Ernest Beutler]355

CHAPTER 30 CLINICAL MANIFESTATIONS AND CLASSIFICATION OF ERYTHAROCYTE DISORDERS [Allan J. Erslev]369

CHAPTER 31 APLASTIC ANEMIA [Richard K. Shadduck]375

CHAPTER 32 PURE RED CELL APLASIA [Allan J. Erslev]391

CHAPTER 33 ANEMIA OF CHRONIC RENAL FAILURE [Jaime Caro/Allan J. Erslev]399

CHAPTER 34 ANEMIA OF ENDOCRINE DISORDERS [Allan J. Erslev]407

CHAPTER 35 THE CONGENITAL DYSERYTHROPOIETIC ANEMIAS [Ernest Beutler]413

CHAPTER 36 PAROXYSMAL NOCTURNAL HEMOGLOBINURIA [Ernest Beutler]419

CHAPTER 37 THE MEGALOBLASTIC ANEIAS [Bernard M. Babior]425

CHAPTER 38 IRON DEFICIENCY [Virgil F. Fairbanks/Ernest Beutler]447

CHAPTER 40 ANEMIA ASSOCIATED WITH MARROW INFILTRATION [Allan J. Erslev]447

CHAPTER 39 ANEMIA DUE TO OTHER NUTRITIONAL DEFICIENCIES [Ernest Beutler]471

CHAPTER 41 ANEMIA OF CHRONIC DISEASE [Allan J. Erslev]481

CHAPTER 42 DISORDERS OF IRON STORAGE AND TRANSPORT [Virgil F. Fairbanks/David J. Brandhagen]498

CHAPTER 43 HEREDITARY SPHEROCYTOSIS, ELLIPTOCYTOSIS, AND RELATED DISORDERS [Patrick G. Gallagher/Bernard G.Forget]503

CHAPTER 44 ACANTHOCYTOSIS, STOMATOCYTOSIS, AND RELATED DISORDERS [Patrick G. Gallagher]519

CHAPTER 45 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND OTHER RED CELL ENZYME ABNORMALITIES [Ernest Beutler]527

CHAPTER 46 THE THALASSEMIAS [David J. Weatherall]547

CHAPTER 47 THE SICKLE CELL DISEASES AND RELATED DISORDERS [Ernest Bertler]581

CHAPTER 48 HEMOGLOBINOPATHIES ASSOCIATED WITH UNSTABLE HEMOGLOBIN [Ernest Beutler]607

CHAPTER 49 METHEMOGLOBINEMIA AND OTHER CAUSES OF CYANOSIS [Ernest Beutler]611

CHAPTER 50 TRAUMATIC CARDIAC HEMOLYTIC ANEMIA [Allan J. Erslev]619

CHAPTER 51 MICROANGIOPATHIC HEMOLYTIC ANEMIA [Jose Martinez]623

CHAPTER 52 MARCH HEMOGLOBINURIA, SPORTS ANEMIA, AND SPACE ANEMIA [Allan J. Erslev]627

CHAPTER 53 HEMOLYTIC ANEMIA DUE TO CHEMICAL AND PHYSICAL AGENTS [Ernest Beutler]629

CHAPTER 54 HEMOLYTIC ANEMIA DUE TO INFECTIONS WITH MICROORGANISMS [Ernest Beutler]633

CHAPTER 55 ACQUIRED HEMOLYTIC ANEMIA DUE TO WARM-REACTING AUTOANTIBODIES [Charles H. Packman]639

CHAPTER 56 CRYOPATHIC HEMOLYTIC SYNDROMES [Charles H. Packman]649

CHAPTER 57 DRUG-RELATED IMMUNE HEMOLYTIC ANEMIA [Charles H. Packman]657

CHAPTER 58 ALLOIMMUNE HEMOLYTIC DISEASE OF THE NEWBORN [Jayashree Ramasethu/Naomi L. C. Luban]665

CHAPTER 59 ACUTE BLOOD LOSS ANEMIA [Robert S. Hillman/Chaim Hershko]677

CHAPTER 60 HYPERSPLENISM AND HYPOSPLENISM [Allan J. Erslev]683

CHAPTER 61 POLYCYTHEMIA [Ernest Beutler]689

CHAPTER 62 THE HEMATOLOGIC ASPECTS OF PORPHYRIA [Shigeru Sassa]703

CHAPTER 63 HEREDITARY AND ACQUIRED SIDEROBLASTIC ANEMIAS [Ernest Beutler]721

PART VI NEUTROPHILS, EOSINOPHILS, BASOPHILS AND MAST CELLS729

CHAPTER 64 MORPHOLOGY OF NEUTROPHILS, EOSIOPHILS, AND BASOPHILS [Dorothy Ford Bainton]729

CHAPTER 65 COMPOSITION AND METABOLISM OF NEUTROPHILS [Ernest Beutler]745

CHAPTER 66 PRODUCTION. DISTRIBUTION. AND FATE OF NEUTROPHILS [Bernard M. Babior/David W. Golde]753

CHAPTER 67 FUNCTIONS OF NEUTROPHILS [James E. Smolen/Laurence A. Boxer]761

CHAPTER 68 EOSINOPHILS AND THEIR DISORDERS [A. J. Wardlaw/A. Barry Kay]785

CHAPTER 69 BASOPHILS AND MAST CELLS AND THEIR DISORDERS [Stephen J. Galli, Dean D. Metcalfe,Ann M. Dvorak]801

CHAPTER 70 CLASSIFICATION AND CLINICAL MANIFESTATIONS OF NEUTROPHIL DISORDERS [Marshall A. Lichtman]817

CHAPTER 71 NEUTROPENIA AND NEUTROPHILIA [David C. Dale]823

CHAPTER 72 NEUTROPHIL DISORDERS: QUALITATIVE ABNORMALITIES OF THE NEUTROPHIL [Laurence A. Boxer]835

PART VII　MONOCYTES AND MACROPHAGES855

CHAPTER 73 MORPHOLOGY OF MONOCYTES AND MACROPHAGES [Steven D. Douglas/Wen-Zhe Ho]855

CHAPTER 74 BIOCHEMISTRY AND FUNCTION OF MONOCYTES AND MACROPHAGES [Robert I. Lehrer/Tomas Ganz]865

CHAPTER 75 PRODUCTION. DISTRIBUTION. AND FATE OF MONOCYTES AND MACROPHAGES [Tomas Ganz/Rober I. Lehrer]873

CHAPTER 76 CLASSIFICATION AND CLINICAL MANIFESTATIONS OF DISORDERS OF MONOCYTES AND MACROPHAGES [Marshall A. Lichtman]877

CHAPTER 77 MONOCYTOSIS AND MONOCYTOPENIA [Marshall A. Lichtman]881

CHAPTER 78 INFLAMMATORY AND MALIGNANT HISTIOCYTOSIS [Marshall A. Lichtman/Camille N. Abboud]887

CHAPTER 79 LIPID STORAGE DISEASES [Ernest Beutler]899

CHAPTER 80 MORPHOLOGY OF LYMPHOCYTES AND PLASMA CELLS [Stephen M. Baird]911

PART VIII LYMPHOCYTES AND PLASMA CELLS911

CHAPTER 81 COMPOSITION AND BIOCHEMISTRY OF LYMPHOCYTES AND PLASMA CELLS [Thomas J. Kipps/Dennis A. Carson]919

CHAPTER 82 LYMPHOCYTE ONTOGENY [Tucker W. LeBien/Fred E. Bertrand]927

CHAPTER 83 FUNCTIONS OF B LYMPHOCYTES AND PLASMA CELLS IN IMMUNOGLOBULIN PRODUCTION [Thomas J. Kipps]937

CHAPTER 84 FUNCTIONS OF T LYMPHOCYTES:T-CELL RECEPTORS FOR ANTIGEN [Thomas J. Kipps]949

CHAPTER 85 FUNCTIONS OF NATURAL KILLER CELLS [Giorgio Trinchieri/Lewis L. Lanier]959

CHAPTER 86 CLASSIFICATION AND CLINICAL MANIFESTATION OF LYMPHOCYTE AND PLASMA CELL DISORDERS [Thomas J. Kipps]965

CHAPTER 87 LYMPHOCYTOSIS AND LYMPHOCYTOPENIA [Thomas J. Kipps]969

CHAPTER 88 IMMUNODEFICIENCY DISEASES [Fred S. Rosen]977

CHAPTER 89 ACQUIRED IMMUNODEFICIENCY SYNDROME(AIDS) [Howard A. Liebman/Timothy P. Cooley/Alexandra M. Levine]985

CHAPTER 90　MONONUCLEOSIS　SYNDROMES [Kuo-Liang Huang/Robert F. Betts]1011

PART IX MALIGNANT DISEASES1017

CHAPTER 91 CLASSIFICATION AND CLINICAL MANIFESTATIONS OF THE CLONAL MYELOID DISORDERS [Marshall A. Lichtman/James K. Brennan]1017

CHAPTER 92 MYELODYSPLASTIC DISORDERS (INDOLENT CLONAL MYELOID DISEASES AND OLIGOBLASTIC LEUKEMIA)[Marshall A.Lichtman/James K.Brennan]1029

CHAPTER 93 ACUTE MYELOGENOUS LEUKEMIA [Marshall A. Lichtman/Jane L. Liesveld]1047

CHAPTER 94 CHRONIC MYELOGENOUS LEUKEMIA AND RELATED DISORDERS [Marshall A. Lichtman/Jane L. Liesveld]1085

CHAPTER 95 IDIOPATHIC MYELOFIBROSIS(AGNOGENIC MYELOID METAPLASIA) [Marshall A. Lichtman]1125

CHAPTER 96 CLASSIFICATION OF MALIGNANT LYMPHOID DISORDERS [Thomas J. Kipps]1137

CHAPTER 97 ACUTE LYMPHOBLASTIC LEUKEMIA [Ching-Hon Piu]1141

CHAPTER 98 CHRONIC LYMPHOCYTIC LEUKEMIA AND RELAED DISEASES [Thomas J. Kipps]1163

CHAPTER 99 HAIRY CELL LEUKEMIA [Alan Saven]1195

CHAPTER 100 LARGE GRANULAR LYMPHOCYTIC LEUKEMIA [Thomas P. Loughran/Marshall E. Kadin]1203

CHAPTER 101 PATHOLOGY OF MALIGNANT LYMPHOMAS [Peter M. Banks]1207

CHAPTER 102 HODGKIN LYMPHOMA [Sandra J. Horning]1215

CHAPTER 103 LYMPHOMAS [Kenneth A. Foon/Richard I. Fisher]1237

CHAPTER 104 PLASMA CELL NEOPLASMS: GENERAL CONSIDERATIONS [Stephen M. Baird]1263

CHAPTER 105 ESSENTIAL MONOCLONAL GAMMOPATHY [Marshall A. Lichtman]1271

CHAPTER 106 PLASMA CELL MYELOMA [Bart Barlogie/John Shaughnessy/Nikhil Munshi/Joshua Epstein]1279

CHAPTER 107 THE AMYLOIDOSIS [Joel N. Buxbaum/Daniel R. Jacobson]1305

CHAPTER 108 WALDENSTROM MACROGLOBULINEMIA [Thomas J. Kipps]1317

CHAPTER 109 HEAVY-CHAIN DISEASES [Joel N. Buxbaum/Alice Alexander]1327

PART X HEMOSTASIS AND THROMBOSIS1339

CHAPTER 110 MEGAKARYOPOIESIS AND THROMBOPOIESIS [David J. Kuter]1339

CHAPTER 111 PLATELET MORPHOLOGY，BIOCHEMISTRY AND FUNCTION [Leslie V. Parise/Susan S. Smyth/Barry S. Coller]1357

CHAPTER 112 MOLECULAR BIOLOGY AND BIOCHEMISTRY OF THE COAGULATION FACTORS AND PATHWAYS OF HEMOSTASIS [Harold R. Roberts/Dougald M. Monroe Ⅲ/Maureane Hoffman]1409

CHAPTER 113 CONTROL OF COAGULATION REACTIONS [John H. Griffin]1435

CHAPTER 114 VASCULAR FUNCTION IN HEMOSTASIS [Katherine A. Hajjar/Naomi L. Esmon/Aaron J. Marcus/William Muller]1451

CHAPTER 115 CLASSIFICATION, CLINICAL MANIFESTATIONS AND EVALUATION OF DISORDERS OF HEMOSTASIS [Uri Seligsohn/Barry S. Coller]1471

CHAPTER 116 MOLECULAR MECHANISMS OF FIBRINOLYSIS [Katherine A. Hajjar]1479

CHAPTER 117 THROMBOCYTOPENIA [James N. George/Mujahid A. Rizvi]1495

CHAPTER 118 THROMBOCYTOSIS AND ESSENTIAL THROMBOCYTHEMIA [Andrew I. Schafer]1541

CHAPTER 119 HEREDITARY QUALITATIVE PLATELET DISORDERS [Barry S. Coller/Deborah L. French]1551

CHAPTER 120 ACQUIRED QUALITATIVE PLATELET DISORDERS DUE TO DISEASES. DRUGS. AND FOODS [Sanford J. Shattil/Charles S. Abrams/Joel S. Bennett]1583

CHAPTER 121 THE VASCULAR PURPURAS [Paul I. Schneiderman]1603

CHAPTER 122 INHERITED DEFICIENCIES OF COAGULATION FACTORS Ⅱ.Ⅴ.Ⅶ.Ⅸ.AND XIII AND THE COMBINED DEFICIENCIES OF FACTORS V AND VIII OF THE VIAMIN K-DEPENDENT FACTORS [Uri Seligsohn/Gilbert C. White.Ⅱ]1617

CHAPTER 123 HEMOPHILIA A AND HEMOPHILIA B [Harold R. Roberts/Maureane Hoffman]1639

CHAPTER 124 HEREDITARY ABNORMALITIES OF FIBRINOGEN [Michael W. Mosesson]1659

CHAPTER 125 HEMOSTATIC DYSFUNCTION RELAED TO LIVER DISEASES AND LIVER TRANSPLANTATION [Eberhard F. Mammen]1673

CHAPTER 126 DISSEMINATED INTRAVASCULAR COAGULATION [Uri Seligsohn]1677

COLOR PLATES I-XXV(BETWEEN PAGES 1676 AND 1677)1677

CHAPTER 127 HEREDITARY THROMBOPHILIA [Scott H. Goodnight/John H. Griffin]1697

CHAPTER 128 THE ANTIPHOSPHOLIPID SYNDROME [Jacob H. Rand]1715

CHAPTER 129 VENOUS THROMBOSIS [Gary E. Raskob/Russell D. Hull/Graham F. Pineo]1735

CHAPTER 130 ATHEROSCLEROSIS, THROMBOSIS,AND CORONARY ARTERY DISEASE [Mark B. Taubman]1743

CHAPTER 131 ANTIPLATELET THERAPY [Harvey J. Weiss]1763

CHAPTER 132 ORAL ANTICOAGULATION [Sam Schulman]1777

CHAPTER 133 HEPARIN, HIRUDIN, AND RELATED AGENTS [Gary E. Raskob/Russell D. Hull/Graham F. Pineo]1793

CHAPTER 134 FIBRINOLYTIC THERAPY [Joseph Loscalzo]1803

CHAPTER 135 VON WILLEBRAND DISEASE [David Ginsburg]1813

CHAPTER 136 DISORDERS OF FIBRINOLYSIS AND USE OF ANTIFBRINOLYTIC AGENTS [Frdor Bachmann]1829

PART XI TRANSFUSION MEDICINE1843

CHAPTER 137 ERYTHROCYTE ANTIGENS AND ANTIBODIES [Loni Calhoun/Lawrence D. Petz]1843

CHAPTER 138 HUMAN LEUKOCYTE AND PLATELET ANTIGENS [Karen A. Sullivan/Thomas J. Kipps]1859

CHAPTER 139 BLOOD PROCUREMENT AND SCREENING [Jeffrey McCullough]1871

CHAPTER 140 PRESERVATION AND CLINICAL USE OF ERYTHROCYTES AND WHOLE BLOOD[Ernest Beutler]1879

CHAPTER 141 COLLECTION AND TRANSFUSION OF LEUKOCYTES, DENDRITIC CELLS, AND STEM CELLS [Nicholas A. Bandarenko/Mark E. Brecher]1893

CHAPTER 142 PRESERVATION AND CLINICAL USE OF PLATELETS [Scott Murphy]1905

CHAPTER 143 PREPARATION AND CLINICAL USE OF PLASMA AND PLASMA FRACTIONS [Kenneth D. Friedman/Jay E. Menitove]1917

CHAPTER 144 THERAPEUTIC HEMAPHERESIS: INDICATIONS, EFFICACY, COMPLICATIONS [Bruce C. Mcleod]1935

INDEX1943